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Description:

Who We Are
The Gladstone Institutes is a leading independent, not-for-profit research organization dedicated to improving human health through groundbreaking biomedical research and education. Our work spans neuroscience, cardiovascular biology, immunology, and stem cell biology, with a strong emphasis on understanding and treating disease. With approximately 600 team members, including world-renowned scientists and biomedical leaders, Gladstone fosters a collaborative and innovative environment. Located at the Mission Bay Campus in a state-of-the-art facility, we offer competitive salaries, comprehensive benefits, and the resources to empower individuals to maximize their potential and make a meaningful impact on global health.

About the Role
The Ramani Lab at Gladstone Institutes is seeking a highly motivated Research Associate to support wet-lab research initiatives. The Ramani Lab specializes in the development and application of cutting-edge sequencing technologies to investigate transcriptional regulation at a genome-wide scale. Research
Associates will be expected to help build on recent studies from the lab have focused on understanding chromatin fiber structure in the contexts of regulated transcription and DNA replication (Ostrowski et al, Cell [2025]; Moore et al, Science [2025]; Yang et al, Nature [2026]).

The Research Associate will specifically be responsible for (1) aiding with lab organization and ordering; (2) supporting the lab’s biochemistry pipeline for creating and characterizing chromatin in vitro through a combination of protein purification, molecular biology, and genomics data analysis, and (3) generating
single-cell and single-molecule sequencing libraries compatible with Illumina and PacBio sequencing platforms. The ideal candidate will have a strong background in molecular biology, excellent organizational and communication skills, and the ability to work independently. Prior Research Associates have successfully matriculated to top molecular biology PhD programs in the US including at UCSF, MIT, the University of Washington, and Columbia.

What you will do:

• Perform biochemical techniques such as protein purification and in vitro reconstitution of molecular processes.
• Conduct molecular biology experiments to create sequencing libraries for high-throughput sequencing platforms.
• Develop and optimize molecular biology protocols, including barcoding, amplification, and processing of DNA and RNA from mammalian cells.
• Assist with lab organization, including reagent procurement and inventory management.
• Collaborate with team members to analyze and interpret sequencing data

What you will need:

• B.S./B.A. degree in a relevant scientific field by the time of hire.
• Prior experience in protein purification and biochemistry.
• Candidates currently completing their degree may apply, but the degree must be conferred by the appointment start date.

What is preferred:

• Experience with high-throughput sequencing technologies, including Illumina, Pacific Biosciences, or Oxford Nanopore.
• Experience with molecular biological protocols.
• Familiarity with mammalian tissue culture techniques.
• Proficiency in bioinformatics or scripting languages such as UNIX, C++, Python, or R.

Salary Range:

$28.35/hr. ($58,968) - $32.67/hr. ($67,949)

Gladstone Perks & Benefits

• People –work with talented, committed, and supportive teammates within an organization that values each member of its community.

• A meaningful place to grow and learn –whether it’s your professional skills or scientific knowledge, we have the resources and environment to advance either so you can better support Gladstone’s mission to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and excellent environment.

• Healthy work/life balance –you are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work.

• Compensation –competitive salary. Title and salary will be commensurate with education and experience.

• Excellent benefits –generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.
  
  

Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, sex, religion, national origin, ancestry, age, marital status, medical condition, physical or mental disability, veteran status, sexual orientation, or any other non-job related characteristic. We make all employment decisions so as to further this principle of equal employment.