Contract Research Associate/Sr. Research Associate (Discovery Chemistry)

Position located in Burlington, MA

Responsibilities:

• Perform routine laboratory functions and maintain, calibrate, and set up laboratory instruments and equipment.
• Perform synthesis of chemically modified oligonucleotides and peptides using automated instruments. Experience with MerMade/AKTA oligonucleotide synthesizers, and Liberty Blue/Aaptec peptide synthesizers desirable.
• Perform multi-step small molecule reactions to generate ligands for downstream bioconjugation projects.
• Work closely with senior scientists to design and conduct novel oligonucleotide
• conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.
• Data management and documentation: Maintain accurate, organized experimental records and reagent inventories in electronic lab notebooks (ELNs) on a regular basis.
• Act as member of a multidisciplinary research team, assisting with development of project strategy, analysis and communication of complex data.

Requirements:

• B.S./M.S. in chemistry or related fields with 0-4 years of relevant experience, preferably in an industrial setting.
• Experience in organic chemistry and multi-step organic synthesis
• Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is preferred
• Experience using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase, Ion exchange chromatography (HPLC/UPLC), ESI-MS and MALDI-TOF Mass Spectrometry (LC-MS) is a plus.
• Experienced in using electronic lab notebooks (ELNs) for data documentation and management.

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