Pros
The Hillsboro site has undergone a huge transformation over the past 2 1/2 years. Teams are hitting major milestones and collaboration has improved greatly. Senior Management is listening and has made noticable efforts to improve the working culture. Nearly all the people who contributed to the problems in 2011 are long gone, replaced with the exceptional talent that one would expect to find at Genentech.
Cons
Business processes are still too complex and decision making is still too slow. There still are a handful of people who are only looking out for themselves, which make it hard for the rest of us. Work/life balance is still a challenge, people in some groups are getting burned-out while others don't seem to pick up the slack. Some middle managers need to put their egos aside and focus on doing the right things for the business over what's best for them.