Pros
In the IT half of the company, it's easy to get recognition for doing a good job. If you carry a "think like an owner" mentality, it will get you far. Most people in the company have blinders on and can't see the bigger picture, so if you can break-free of that mindset, do a good job, and show people how beneficial actions like that can be, you'll get recognized. The company has recognized that the current way of doing business isn't sustainable, so they are implementing changes to change course. They're doing it from the top-down by removing incompetent manager and they're doing it from the bottom-up by hiring employees with the mindset they want to foster. Also, many people who work there are willing to help when you need it, even if they already have a lot to do themselves. McKesson's IT half is definitely changing, so it's a great place to be if you're willing to put forth the effort and assist with the change.
Cons
It's definitely a corporation. If you don't like wearing collared shirts and dress slacks, this isn't the place to work. The inertia of the "that's the way we've always done it" mentality can be hard to break, even when trying to implement a quick, easy change.