The biggest con is that we work in a highly regulated environment. I have no doubt that our legal and healthcare compliance group are doing great work and keeping the company safe, but it can be frustrating to hear "No, you can't do that" a lot. That's more of a feature of the industry than GNE, however.
Some groups have competing areas of expertise/function, so it can be difficult to take on projects without sensing some resistance from the other group.