You can't eat prestige (horrible work life balance, toxic culture of fear, very political)
Pros
Interesting science if you are in the right group
Cons
Manager/PI explicitly told me that 60-70 hr work weeks are expected from RAs -- for a 50k salary in Boston. PIs will bully you and tell you you're not capable of anything while also assigning you enough work for three people. They control you by holding rec letters hostage because they know most people use these positions as a stepping stone to graduate school. If you complain to HR and your PI is well-known, they won't do anything. No accountability. The Broad churns through young, motivated, ambitious researchers who genuinely care about their work, exploits them for all they're worth, and then moves on to the next batch. In the year that I worked at the Broad I saw three coworkers leave for non-science roles after they had worked their whole lives to be scientists. It should be a major red flag that after getting (sometimes multiple) degrees in biology, doing research and industry internships, and having every intention to continue in this field, working here is bad enough to make someone change careers entirely. Avoid this place if you want to continue in science because the Broad will kill your love for biology. My advice to early career researchers is to work for a place that adequately compensates you (prestige won't pay your rent, and once you're here you realize it's not that great anyway), preferably has a union, and allows you to talk to lab members without the PI present during the interview process. Do NOT blindly trust what a PI says. They will lie to get you to sign that job contract and turn on you the second they're able.